Dietary Intake of Antioxidants and Serum Levels of Total Antioxidant Status (TAS) in MS Patients with that of Normal Subjects

Hejazi E1, Amaani R2, Sharafodin-zadeh N3 1. M.sc Student of Nutritional Sciences, Department of Nutritional, Faculty of Para-Medicine, Jondi-shapour University of Medical Sciences 2. Associate Professor, Department of Nutritional, Faculty of Para-Medicine, Jondi-shapour University of Medical Sciences 3. Assistant Professor, Department of Neurology, Faculty of Medicine, Jondi-shapour University of Medical Sciences Abstract Background: Multiple Sclerosis (MS) is a chronic, immune-mediated inflammatory and neurodegenerative disease of the Central Nervous System (CNS), with an etiology that is not yet fully understood. Increasing evidence shows that oxidative stress plays an important role in the pathogenesis of MS. The aim of this study was to compare dietary intake of antioxidants and serum levels of Total Antioxidant Status (TAS) in MS patients with that of normal subjects. Materials and methods: Serum levels of TAS and dietary intake of the main antioxidants of twenty one MS patients (16 women) were compared with age and gender matched healthy controls. Serum samples were collected and frozen for further spectrophotometer analysis. Food frequency questionnaires and 24-hour dietary recalls for 3 days of all subjects were obtained. Results: There was no significant difference in serum levels of TAS between the two groups. No significant difference was seen in consumption of dietary antioxidant sources between them. Additionally, daily intake of vitamin C, vitamin E, vitamin A, folate and dietary fiber were not significantly different between groups. Conclusion: There is a lack of evidence on the possible relationship and benefits of dietary antioxidant in MS patients. More research is required to assess the effectiveness of diet interventions on antioxidant status in MS patients.